Synthesis of mono-O-alkylated homooxacalix[3]arene and a protection–deprotection strategy for homooxacalix[3]arene

Wu, Chong; Ikejiri, Yusuke; Zeng, Xi (Chemist); Elsegood, Mark R. J.; Redshaw, Carl; Yamato, Takehiko

School of Mathematics and Physical Sciences
Mono-O-alkylated homooxacalix[3]arene ; Homooxacalix[3]arene
2017

Journal article


Rights
©2017 University of Hull
Alternative title
Alkylated homooxacalix[3]arene and an efficient protection-deprotection strategy for homooxacalix[3]arene
Abstract

The regioselective synthesis of mono-O-alkylated homooxacalix[3]arene is accomplished for the first time. The synthetic route relies on two key steps: (i) a facile protection of two OH groups at the lower rim of the homooxacalix[3]arene and (ii) the deprotection of 9-anthrylmethyl groups via the Pd/C-catalyzed hydrogenation under atmospheric hydrogen. An efficient protection–deprotection strategy for the functionalization of homooxacalix[3]arene is presented.

Publisher
The University of Hull
Peer reviewed
Yes
Language
English
Extent
519 KB
Identifier
hull:14118

Journal

Journal title
Organic letters
Publication date
2017
Publisher
American Chemical Society
DOI
10.1021/acs.orglett.6b03338
ISSN (Print)
1523-7060
ISSN (Electronic)
1523-7052
Volume
19
Issue
1
Start page
66
End page
99
Notes

Authors' accepted manuscript of article published in: Organic letters, 2017, v.19, issue 1.

Link
Published article
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