Investigation into the effects of neuromodulation

Akbar, Muhammad Jawaid

Medicine
February 2017

Thesis or dissertation


Rights
© 2017 Muhammad Jawaid Akbar. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder.
Abstract

Introduction: This thesis investigates the putative role of neuromodulation on bowel motility and the use of temporary neuromodulation as a tool for patient selection for permanent gastric neuromodulation. It also examines the durability of neuromodulation effects on the short and long-term basis.

Methodology: My preliminary studies involved a systemic review of different neuromodulations and assessment of GI motility with capsule endoscopy. After this I measured gastric emptying time, quality of life and nutritional status following temporary gastric neuromodulation (GNM) and permanent gastric neuromodulation.

Results: In our prospective study temporary and permanent gastric neuromodulation improved gastric emptying time, quality of life and nutritional intake of the patients. An interesting result of my study was the validation of capsule endoscopy (CE) as a tool for assessing GI motility.

Conclusions:
1 GNM is an effective treatment option for the symptoms of drug-resistant gastroparesis.
2. Temporary GNM helps in patient selection for permanent GNM.
3. Capsule endoscopy may be used to assess GI motility.

Publisher
Hull York Medical School, The University of Hull and University of York
Qualification level
Masters
Qualification name
MSc
Language
English
Extent
14 MB
Identifier
hull:15134
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