A quinoline-based fluorometric and colorimetric dual-modal pH probe and its application in bioimaging

Zhu, Qin; Li, Zhao; Mu, Lan (Chemist); Zeng, Xi (Chemist); Redshaw, Carl; Wei, Gang (Chemist)

Department of Chemistry
Quinoline; pH probe; Fluorometric; Colorimetric; Bioimaging
2018

Journal article


Rights
©2018, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

The compound (E)-8-hydroxyl-2-[(E)-2-(2, 4-dihydroxyphenyl)vinyl]-quinoline (1) has been developed as a fluorometric and colorimetric dual-modal probe for pH detection in solution and in vivo. Remarkable changes in the fluorescence intensity with large Stokes shifts and colorimetric responses were observed as a function of pH. The sensing mechanisms involving protonation and deprotonation processes over the acidic and alkaline pH ranges were confirmed by 1H NMR and IR spectroscopic analysis. Furthermore, the application of probe 1 for the imaging of live PC3 cells was successfully achieved. Test strips based on probe 1 were fabricated, and were found to act as a convenient and efficient pH test kits.

Publisher
The University of Hull
Peer reviewed
Yes
Language
English
Extent
1 MB
Identifier
hull:15411

Journal

Journal title
Spectrochimica acta part A : molecular and biomolecular spectroscopy
Publication date
2018
Publisher
Elsevier
DOI
10.1016/j.saa.2017.06.071
ISSN (Print)
1386-1425
Volume
188
Start page
230
End page
236
Notes

Authors' accepted manuscript of article published in: Spectrochimica acta part A : molecular and biomolecular spectroscopy, 2018, v.188

Link
Published article
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